Stem Cell Signature Treatments – SEFFILLER Technique

The body’s own stem cells can replace damaged cells, rejuvenating the skin or restoring hair growth, for example. The possibilities are endless.

(Picture: SEFFILLER/SEFFIHAIR training at UMA clinic te Amsterdam)

Autologous regenerative therapy with the body's own stem cells. SEFFILLER training at UMA clinic in Amsterdam.

Stimulate hair growth with SEFFIHAIR®

Stop hair loss and stimulate new hair growth with the body’s own stem cells.

Stem Cell Lipofilling with Your Own Fat

Natural volume restoration as an alternative to fillers.

Natural skin rejuvenation with body-own fat and regenerative stem cells

At Kliniek Dokter Brandt in Amsterdam, we offer our exclusive Stem Cell Signature Treatments, performed with the advanced SEFFILLER® technique. This treatment uses body-own fat tissue that is naturally rich in regenerative stem cells and growth factors.

This innovative treatment combines the power of your own body with modern techniques from regenerative medicine for a natural improvement of skin quality, volume and appearance.

By using your own fat tissue, we support the skin’s natural processes and can contribute to firmer, smoother and fresher-looking skin. The treatment offers a body-own alternative to traditional fillers and can be applied to areas such as the face, neck, décolleté, hands, body (such as hip dips) and the intimate area.

Every treatment is fully tailored to your personal wishes, skin condition and desired results.

Our Stem Cell Signature Treatments

At Kliniek Dokter Brandt, we offer two variations of our Stem Cell Signature Treatments: the Classic and the Advanced. Both treatments use body-own fat tissue and are focused on natural skin improvement, skin rejuvenation and restoring skin quality.

Stem Cell Signature Classic

Microfat + nanofat + microneedling

The Stem Cell Signature Classic combines microfat and nanofat therapy according to the SEFFILLER® technique with microneedling.

During the treatment, a small amount of body-own fat tissue is harvested and carefully processed into microfat or nanofat. This is then combined with microneedling, where controlled micro-channels are created in the skin to stimulate natural skin renewal and collagen production.

This combination supports skin structure and contributes to a more even, smoother and fresher appearance.

Suitable for:

Fine lines and early signs of skin aging
Mild volume loss and subtle restoration of skin structure
Area around the eyes and tear troughs
Improvement of skin quality and skin texture
A healthy, fresh appearance
Face, neck, décolleté and hands
Patients looking for a natural alternative to traditional fillers

Stem Cell Signature Advanced

Microfat + nanofat + advanced skin tightening techniques

The Stem Cell Signature Advanced is our most comprehensive regenerative treatment. It combines microfat and nanofat therapy with additional techniques for enhanced skin tightening, collagen stimulation and contour improvement.

Depending on your skin condition and treatment goals, the treatment can be combined with:

RF Microneedling / Morpheus8

A combination of microneedling and radiofrequency energy that stimulates deeper skin layers and is focused on skin tightening, improving skin structure and supporting collagen production.

Endolifting

A minimally invasive laser treatment that stimulates the skin from within and can contribute to skin tightening and collagen remodeling.

Collagen-stimulating treatment with Radiesse®

Radiesse can be used as a collagen stimulator to support skin quality, firmness and natural contours.

By strategically combining these techniques, a personalized regenerative approach is created, focused on skin quality, firmness and a natural result.

Suitable for:

Advanced skin aging
More pronounced skin laxity
Loss of volume and contour definition
Improvement of the face, neck, décolleté and body
Patients looking for a natural alternative to traditional fillers or more intensive procedures

SEFFILLER® – natural rejuvenation with body-own fat tissue

SEFFILLER® is an innovative form of regenerative lipofilling using body-own fat tissue.

This fat tissue naturally contains regenerative stem cells and growth factors that contribute to supporting skin quality, volume restoration and a natural appearance.

With the SEFFILLER® technique, a small amount of fat tissue is harvested, carefully processed and then reintroduced into areas that benefit from additional support, such as the face, neck, décolleté or hands.

The result is a natural restoration of volume and improvement of skin quality, in harmony with your own appearance.

Microfat and Nanofat: the difference

Within the SEFFILLER® technique, we distinguish between microfat and nanofat.

Microfat consists of carefully purified fat cells and is used for natural volume restoration. It is suitable for areas where volume has been lost, such as the cheeks, temples, jawline and other contour areas.

Nanofat is further refined into a very fine substance rich in regenerative components from the fat tissue. Nanofat is mainly used for skin improvement and can contribute to a more even skin texture, smoother skin and a fresher appearance.

The main difference:

Microfat focuses primarily on volume and contour
Nanofat focuses primarily on skin quality and rejuvenation

In many cases, both techniques are combined for an optimal natural result.

The power of a combined approach

By combining SEFFILLER® with techniques such as microneedling, RF Microneedling / Morpheus8, Endolifting and collagen-stimulating treatments such as Radiesse®, we create a versatile approach focused on:

Skin improvement
Skin tightening
Supporting collagen production
Natural volume restoration
Improvement of skin quality

The goal is always a natural result that matches your face, skin and personal appearance.

Also suitable for hair restoration and the intimate area

The regenerative properties of the SEFFILLER® technique also make this treatment highly suitable for other indications. Nanofat can be applied to support the scalp and beard area, where its regenerative components may contribute to hair growth on the scalp, beard growth, and the quality of both the hair and beard. In addition, the treatment is highly suitable for the intimate area, where autologous fat tissue can be used for the natural augmentation and rejuvenation of the labia majora. This can help improve volume, skin quality, and comfort in a subtle and natural way.

MCT (Meta Cell Technology)

In our Stem Cell Signature Treatments, we can make use of MCT (Meta Cell Technology), an advanced technique for the careful processing of autologous fat tissue. This helps preserve the regenerative components, including stem cells and growth factors, optimally, allowing the fat tissue to be used in a natural way for skin improvement, volume restoration, and tissue regeneration.

Are you looking for a natural skin rejuvenation treatment, regenerative lipofilling or a non-surgical anti-aging solution in Amsterdam?

The Stem Cell Signature Treatments at Kliniek Dokter Brandt, performed with the advanced SEFFILLER® technique, offer a personalized approach using body-own tissue and innovative techniques for skin improvement.

During a personal consultation, we determine which treatment best matches your skin condition, wishes and goals.

Voor en na resultaat van een stamcelbehandeling door Dokter Brandt

Voor- en nafoto van een Microfat stamcelbehandeling van het gezicht met zichtbare verbetering van huidkwaliteit en volume.

Before and after regenerative facial treatment using stem cells, Seffiller, lipofilling, micro- and nanofat in Amsterdam

Before and after regenerative facial treatment using stem cells, Seffiller, lipofilling, micro- and nanofat combined with Morpheus8 microneedling and radiofrequency in Amsterdam

Stem cells regenerative facial before after amsterdam 4

Before and after regenerative facial treatment using stem cells, Seffiller, lipofilling, micro- and nanofat combined with Radiesse collagen-stimulating filler in Amsterdam

Before and after regenerative facial treatment using stem cells for natural volume restoration and skin rejuvenation in Amsterdam

“The demand for natural rejuvenation is growing. More and more people are looking for treatments that do not change who they are, but instead support their own skin quality and the body’s natural regenerative capacity for a fresh, youthful appearance.” Christopher J. Brandt - aesthetic physician KNMG

What does a treatment look like?

Step 1: Harvesting the stem cells

In the superficial fat, a significant number of stem cells are present. We can easily extract a small amount of this superficial fat tissue using a syringe under local anesthesia. Typically, the abdomen, flanks, or legs are commonly chosen for this procedure. The amount we remove is approximately equivalent to a shot of espresso (±30 ml.), so it’s not comparable to a typical liposuction. The area where the fat is ‘harvested’ may feel slightly tender for a few days after the procedure.

Step 2: Filtering the stem cells

After harvesting the fat, the next step involves filtering the stem cells. This can be done in various ways depending on the desired effect. If we aim for both skin improvement and a volumizing effect in the face, we will reintroduce the fat cells and filter out the anesthetic solution. For treatments focused on restoring hair growth, we also filter out the fat cells using a centrifuge. This leaves behind a fluid rich in growth factors and stem cells.

Step 3: The re-implantation of the stem cells

Depending on the desired effect, the stem cells may or may not be re-implanted in combination with the fat cells. In a SEFFILLER treatment, we reintroduce the mix of stem cells and fat cells into the subcutaneous fat of the face using a small cannula. In a SEFFIHAIR treatment, we place the filtered stem cells (without fat cells) back into the scalp using a ‘multi-injector’ that allows us to administer multiple small injections simultaneously. The treatment is performed under local anesthesia using a numbing injection or cream.

Step 4: Recovery and results

In the first few days after the treatment, the skin needs some time to settle. Expect mild swelling, redness, and a slight tenderness. It’s possible to encounter a small blood vessel during the procedure, resulting in a bruise, especially in the area where the stem cells were harvested. Generally, the recovery is mild, and beautiful results are often visible quickly. Optimal results will become apparent once the stem cells have settled in, multiplied, and started replacing old damaged cells. This typically occurs within 3-6 months. Depending on your situation and the desired effect, the treatment may be performed in a course of 2 or 3 sessions for optimal results. The results can last for years.

SEFFILLER Stem Cell Lipofilling with Your Own Fat

SEFFILLER is a groundbreaking ‘fat transfer’ procedure that provides a younger and fuller appearance by harnessing the body’s natural regenerative ability of stem cells. The superficial subcutaneous fat contains significant quantities of ‘mesenchymal stem cells’ (ADSCs) and ‘stromal vascular fraction’ (SVF), in simpler terms: stem cells and growth factors that prompt your skin to regenerate cells, restore volume, stimulate collagen, elastin, new blood vessels, and more. The result: skin improvement and facial rejuvenation. In contrast to temporary fillers, the results can last for years.

SEFFIHAIR Amsterdam

Stop hair loss and stimulate new hair growth met SEFFIHAIR

Hair loss affects 70% of all men and 40% of all women, often having a significant impact on self-image. In men, the overproduction of the enzyme dihydrotestosterone (DHT) plays a crucial role in weakening hair follicles, leading to the typical male pattern baldness with a receding hairline and hair loss on the top of the head. In women, hormonal changes can contribute to hair loss, typically leaving the hairline intact but causing visible thinning of the hair. Learn more about our hair treatments.

Lipofilling of the labia majora with body’s own fat (SEFFIGYN®)

SEFFIGYN® Lipofilling of the Labia Majora with Body’s Own Fat

Lipofilling of the labia is a treatment in which the body’s own fat is used to naturally restore the volume and shape of the outer labia (labia majora). Due to volume loss, for example as a result of aging, hormonal changes, pregnancy, or weight loss, the support of the labia may decrease.

With the SEFFIGYN® method, a small amount of fat is removed under local anesthesia, carefully processed, and then reintroduced into the labia. The use of body’s own fat makes the treatment natural and well integrated into the tissue.

The treatment may contribute to increased comfort, improved contour, and a naturally aesthetic result. View more information about our intimate area treatments.

Behandeling van de intieme zone met G-spot en vulva fillers – kliniek dokter Brandt

Frequently asked questions

What is SEFFILLER?

SEFFILLER is a groundbreaking ‘fat transfer’ procedure that provides a younger and fuller appearance by harnessing the body’s natural regenerative ability of stem cells. The superficial subcutaneous fat contains significant quantities of ‘mesenchymal stem cells’ (ADSCs) and ‘stromal vascular fraction’ (SVF), in simpler terms: stem cells and growth factors that prompt your skin to regenerate cells, restore volume, stimulate collagen, elastin, new blood vessels, and more. The result: skin improvement and facial rejuvenation. Unlike temporary fillers, the results can last for years.

What is SEFFIHAIR?

Hair loss affects 70% of all men and 40% of all women and can significantly impact self-esteem. In men, overproduction of the enzyme dihydrotestosterone (DHT) plays a crucial role in weakening hair follicles, leading to the typical male pattern baldness with a receding hairline (‘temples’) and hair loss on the top of the head. In women, hormonal changes can contribute to hair loss, typically leaving the hairline intact but causing visible thinning of the hair.

SEFFIHAIR is a medical treatment based on ‘autologous regenerative therapy’ (ART), where stem cells are extracted from the body’s own fat and re-implanted into the hairy scalp to stimulate new hair growth. This new technology has been proven safe, effective, and entirely natural.

What is the downtime?

The downtime is minimal and is limited to some local skin reactions at the injection sites (mild redness, swelling, and possibly a bruise for 24-72 hours). The area where the fat is ‘harvested’ may feel slightly tender for a few days. You can comfortably use makeup to conceal any post-treatment effects.

When do I see results?

After a SEFFILLER treatment for the face, you’ll immediately notice a difference due to the volumizing effect of the transplanted fat cells. Around 8-12 weeks later, you’ll observe visible skin improvement; your skin becomes firmer and tighter. The complexion and skin hydration also improve. Optimal results are seen around 6 months, and these results can last for years.

Is a treatment with stem cells safe?

In recent years, extensive scientific research has been conducted on treatments using the body’s own stem cells (ADSCs and SVF), demonstrating not only their high effectiveness but also the minimal risk of side effects. It’s an ‘autologous’ treatment, meaning your own tissue is used. In other words, nothing foreign enters your body. The treatment should be performed by a certified medical professional such as a ‘cosmetic physician KNMG,’ dermatologist, or plastic surgeon with proven experience in administering fillers or autologous fat ‘lipofilling.’

How many treatments are necessary?

Depending on the condition of the skin or the extent of hair loss, it may be beneficial to repeat the treatment. Repeating the procedure can provide an additional ‘boost’ to the regenerative process, enhancing the visibility of even more beautiful results. Discuss with your doctor how many sessions are necessary in your case to achieve the desired effect.